In a world devastated by nuclear war, survivors struggle to live among the ruins under the rule of armed gangs and ruthless tyrants. Kenshiro, heir to Hokuto Shinken, a deadly martial art capable of destroying the body from within by striking vital points, travels across the wasteland in search of Yuria, the woman he loves. His journey brings him into conflict with numerous opponents, including other martial arts masters connected to his past and to his fighting school. Behind the spectacular battles, Kenshiro gradually becomes a symbol of hope for the oppressed while confronting the rivalries, sacrifices, and tragedies surrounding the legacy of Hokuto Shinken.