In the 18th century, long before Seiya’s era, a new Holy War is about to begin between Athena and Hades. Tenma, a young orphan who becomes the Pegasus Saint, discovers that his childhood friend Alone has been chosen as the vessel for the god of the Underworld. Meanwhile, Athena is incarnated as Sasha, Alone’s sister, shattering the bond that once united the three friends as a divine conflict threatens all of humanity. Alongside the Gold Saints and the other warriors of the Sanctuary, Tenma tries to save Alone while facing Hades’ Specters and the trials of a war in which destiny, sacrifice, and friendship are constantly put to the test.