One night, the Baxter Building is invaded by strange creatures made of negative energy that have reached Earth by using a human host. To understand the origin of the attack, Reed Richards, Sue Storm, Johnny Storm, and Ben Grimm have no choice but to return to the Negative Zone, an antimatter universe as fascinating as it is dangerous. Their expedition brings them face to face with an enemy connected to an earlier Fantastic Four adventure and a plan capable of threatening far more than their own world. Through cosmic exploration, science, and spectacular battles, the team must once again rely on its ingenuity and family bond to prevent a catastrophe on a universal scale.