The Bureau for Paranormal Research and Defense is an organization tasked with investigating supernatural phenomena and protecting humanity from occult threats. After Hellboy’s departure, its agents — including Abe Sapien, Liz Sherman, Johann Kraus, and several new recruits — continue carrying out missions around the world. What begins as a series of paranormal investigations gradually grows into something much larger as ancient creatures, cults, and apocalyptic forces begin transforming the planet. Faced with catastrophes that become increasingly difficult to contain, the B.P.R.D. slowly becomes one of humanity’s last lines of defense against extinction.