A vast army from the Negative Zone, led by Annihilus, launches a devastating offensive against the known universe. Entire worlds fall as the major cosmic powers struggle to resist this wave of extermination. Caught at the heart of the conflict, Nova, the Guardians of the Galaxy, and several major figures of Marvel’s cosmic universe must join forces despite their rivalries. Between interstellar battles, fragile alliances, and massive destruction, the war against Annihilus becomes a struggle for the survival of entire civilizations and for the future of the galaxy itself.