Splinter's sons are about to fight the battle of their lives! As soon as they have recovered from the tragic assault on Burnow Island, Turtles and their allies are caught in a whirlwind of violence that threatens to plunge New York into chaos. While Agent Bishop is fomenting a new plan to destroy the mutants through an unexpected ally, Karai is back, and Shredder's granddaughter plans to take over the head of the Foot clan. Blood is flowing and war is declared... Will the Hamato clan be threatened on every front?