The DC Multiverse is threatened by the Anti-Monitor, a cosmic entity destroying parallel universes with a wave of antimatter. To prevent the annihilation of all existence, the Monitor gathers heroes and villains from different Earths and multiple eras. Superman, Batman, Wonder Woman, Flash, and many other characters must overcome their rivalries to confront a threat unlike anything they have ever faced. As worlds disappear one after another, the survivors struggle to preserve what remains of their realities. Their battle puts the very existence of the Multiverse at stake and could forever transform the history of the DC Universe.