Cletus Kasady, a serial killer obsessed with chaos, becomes the host of a symbiote spawned from Venom and transforms into Carnage. More powerful, unpredictable, and murderous than his predecessor, he leaves a trail of massacres across the world that repeatedly draws Spider-Man, Venom, and other heroes into his path. But the bond between Cletus and his symbiote quickly goes beyond that of a simple host and creature: their minds and violent impulses become almost inseparable. Between escapes, battles against other symbiotes, and conspiracies connected to the origins of their species, Carnage seeks above all to impose his vision of a world freed from every rule.