Carnage returns with a clear objective: to hunt down everyone who has ever bonded with a symbiote in order to recover the fragments of Knull hidden within their bodies and free the god of the symbiotes. Eddie Brock and his son Dylan quickly become central targets in this hunt, while Spider-Man, Venom, and several other heroes try to stop the massacre. As Carnage gathers more power and extends his influence, the conflict grows far beyond a simple battle between symbiotes and threatens to unleash a cosmic force capable of reshaping the balance of Earth.