The reani-Mecs, a group of super-villains, invaded the campus of Upstate University. Invincible must do everything to stop them. But it is not his most difficult fight. Martians, submissive by deformed creatures and apparently invulnerable, are on their way to Earth. Their goal: to exterminate the human race. Invincible and all superheroes all all all team together to save the world!