Although the children of Cosme I share Florence, only Francis, the eldest, can be duke. Yet he is not cut for such a charge, unlike Isabelle, his sister. Many wish to see the future of the Medici in the hands of this bright and free young woman. But by living in his shadow, his brothers hate her. Their jealousy may well mark a turning point in their history. For the first time, the Medici have no enemies but themselves.